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10.3892/etm.2016.3490 170 ZhangL.CaoN.WangY.WangY.WuC.ChengX.et al (2019a)

Since the liver is a major metabolic organ, liver disease is associated with metabolic diseases, such as obesity, insulin resistance, type 2 diabetes (T2DM), and cardiovascular disease

10.1038/s41401-022-00966-8 63

Keywords: ERK1/2, tumorigenesis, Ras-Raf-MAPK pathway, tumor proliferation, tumor invasion, angiogenesis Introduction Recently, the role of Extracellular signal-regulated kinase l and 2 (ERK1/2) in the Ras/Raf/MEK/ERK signaling pathway has received significant attention for its relevance to tumorigenesis (Zhang et al., 2012[148]